eBooks: Medical Problems

Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. * The first focused reference specifically on alcohol and the brain* Details our current understanding of how alcohol impacts the central nervous system* Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse* Includes section on neuroimaging of neurochemical markers and brain function.

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

Intro -- Cognitive, Clinical, and Neural Aspects of Drug Addiction -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Acknowledgement -- Part I Cognitive and learning aspects of drug addiction -- Chapter 1 Executive functioning and substance use disorders -- The concept of executive functioning -- Substance use disorders and executive dysfunction -- The role of dopamine in executive dysfunction in SUD -- Action selection, feedback processing and updating -- SUD, a biopsychosocial executive functioning disorder -- References -- Further reading
Chapter 2 Impulsive behavior in drug addiction: Clinical, cognitive, and neural correlates -- Introduction -- Behavioral definition of impulsivity -- Functional and dysfunctional impulsivity -- Impulsivity as a clinical problem -- Impulsivity in the nonclinical population -- Impulsivity and cognitive distortions -- References -- Chapter 3 The multifaceted nature of risk-taking in drug addiction -- Introduction -- Risk-taking -- Dual-systems theory of decision-making -- Risk-taking in drug addiction and healthy populations -- Risk-taking and feedback and environmental contingency processing
Healthy populations -- Drug-dependent populations -- Domain-specific risk-taking -- Healthy populations -- Drug-dependent populations -- Decision-making biases and risk-taking -- Intolerance of uncertainty in healthy populations -- Intolerance of uncertainty in drug-dependent populations -- Future studies on risk-taking in drug dependence -- References -- Chapter 4 Delay, probability, and effort discounting in drug addiction -- Introduction -- Delay discounting -- Substance abuse -- Probability discounting -- Nicotine -- Alcohol -- Illicit drugs -- Effort discounting -- Impulsivity
Substance abuse -- Future directions -- Conclusion -- References -- Chapter 5 It's all about context: The environment and substance use -- Introduction -- Environmental stimuli can trigger drug seeking -- Discrete stimuli can directly trigger drug seeking -- Relevance of habit formation to addiction -- Discrete stimuli can indirectly trigger drug seeking -- Psychological processes in stimulus elicited drug seeking -- Relevance of the PIT model to addiction -- Drug and context associations -- Contexts can trigger drug craving -- Context can acquire drug-like motivational properties
The psychological processes of conditioned place preference -- Reinstatement effects in the conditioned place preference paradigm -- Relevance of conditioned place preference to the study of addiction -- Limitations of CPP paradigm -- Context can trigger an increase in drug use behavior -- Psychological processes in context reinstatement -- Relevance of context reinstatement to drug addiction -- Summary and conclusion -- References -- Chapter 6 Avoidance learning and behavior in patients with addiction -- Introduction -- Avoidance of physical withdrawal -- Avoidance of negative affect

A deep dive into the spectrum of Autistic experience and the phenomenon of masked Autism, giving individuals the tools to safely uncover their true selves while broadening society’s narrow understanding of neurodiversity “A remarkable work that will stand at the forefront of the neurodiversity movement.”—Barry M. Prizant, PhD, CCC-SLP, author of Uniquely Human: A Different Way of Seeing Autism For every visibly Autistic person you meet, there are countless “masked” Autistic people who pass as neurotypical. Masking is a common coping mechanism in which Autistic people hide their identifiably Autistic traits in order to fit in with societal norms, adopting a superficial personality at the expense of their mental health. This can include suppressing harmless stims, papering over communication challenges by presenting as unassuming and mild-mannered, and forcing themselves into situations that cause severe anxiety, all so they aren’t seen as needy or “odd.” In Unmasking Autism , Dr. Devon Price shares his personal experience with masking and blends history, social science research, prescriptions, and personal profiles to tell a story of neurodivergence that has thus far been dominated by those on the outside looking in. For Dr. Price and many others, Autism is a deep source of uniqueness and beauty. Unfortunately, living in a neurotypical world means it can also be a source of incredible alienation and pain. Most masked Autistic individuals struggle for decades before discovering who they truly are. They are also more likely to be marginalized in terms of race, gender, sexual orientation, class, and other factors, which contributes to their suffering and invisibility. Dr. Price lays the groundwork for unmasking and offers exercises that encourage self-expression, including: • Celebrating special interests • Cultivating Autistic relationships • Reframing Autistic stereotypes • And rediscovering your values It’s time to honor the needs, diversity, and unique strengths of Autistic people so that they no longer have to mask—and it’s time for greater public acceptance and accommodation of difference. In embracing neurodiversity, we can all reap the rewards of nonconformity and learn to live authentically, Autistic and neurotypical people alike.

This unique resource is designed to be a practical, user-friendly guide for pediatricians, primary care providers, and all healthcare providers who work with children with autism spectrum disorder. Diagnosing and Caring for the Child with Autism Spectrum Disorder offers state-of-the art instruction to clinicians on how to recognize, diagnose and assist children with autism spectrum disorders, from early in life to transition to adulthood. This book will also delve into how to support pediatric patients by working with families, and discuss how to best interact with and support these families. The book opens with a comprehensive introduction of ASD and obstacles to diagnosis and common myths. Section Two is devoted to the early recognition of atypical development and reviews the steps in diagnosing autism, including the evaluation, the diagnostic visit, the developmental exam, and the discussion of findings with parents. Section Three covers treatment and interventions for the autism spectrum and includes a discussion on alternative therapies and how to direct parents toward evidence-based or plausible treatments. Section Four and Five addresses special topics that are relevant to the PCP's or pediatrician's long-term relationship with families, including chapters on anxiety, parents, challenging behaviors and common scenarios that occur across childhood for those who have ASD. Later chapters delve more deeply into providing informed, sensitive care for patients with intersecting identities, and discusses how gender identity and cultural perspective and attitudes can impact the pediatric patient with ASD. Engaging, and written in a conversational style, Diagnosing and Caring for the Child with Autism Spectrum Disorder will be an ideal resource for the pediatrician, primary care provider, and all healthcare providers working with children with ASD, providing concrete, step-by-step methods that readers can incorporate into their own practice.

Back Pain: a movement problem is a practical manual to assist all students and clinicians concerned with the evaluation, diagnosis and management of the movement related problems seen in those with spinal pain disorders. It offers an integrative model of posturo-movement dysfunction which describes the more commonly observed features and related key patterns of altered control. This serves as a framework, guiding the practitioner's assessment of the individual patient. Key features: 1. The book explores motor control and functional movement, its development, and explores how and why it is altered in people with back pain. 2. It integrates contemporary science with the insights and experience of extensive clinical practice. 3. The book maps the more common clinical patterns of presentation in those with spinal pain and related disorders. 4. It provides a simple clinical classification system for back pain. 5. Abundantly illustrated to present concepts and to illustrate the difference between so called normal and dysfunctional presentations. 6. Written by a practitioner for practitioners.

Covering all commonly used interventions for acute and chronic low back pain conditions, Evidence-Based Management of Low Back Pain consolidates current scientific studies and research evidence into a single, practical resource. Its multidisciplinary approach covers a wide scope of treatments from manual therapies to medical interventions to surgery, organizing interventions from least to most invasive. No other book makes it so easy to compare the different interventions and treatment approaches, giving you the tools to make better, more informed clinical decisions. A multidisciplinary approach covers treatments from manual therapies to medical interventions to surgery, and many others in between. An interdisciplinary approach enables health care providers to work together. A logical, easy-to-follow organization covers information by intervention type, from least invasive to most invasive. Integration of interventions provides information in a clinically useful way, so it's easier to consider more than one type of treatment or intervention for low back pain, and easier to see which methods should be tried first. 155 illustrations include x-rays, photos, and drawings.

Packed with illustrated treatment techniques, Trigger Point Therapy for Low Back Pain offers effective strategies beginners can practice at home and detailed hands-on protocols health care practitioners can use while working with patients. Find out which of eleven muscles could be causing back pain, then learn specific trigger point treatments and correct underlying perpetuating factors to immediately relieve soreness and tension in these muscles. If you're ready to try a targeted approach to eliminating back pain, this manual will provide you with all the information you need to get started and end low back discomfort once and for all. (http://www.amazon.com)

The Colorado State University Cooperative Extension presents the full text of an article entitled "Nutrition and Cancer," by J. Anderson. The article discusses dietary guidelines to lower cancer risks, including reducing the intake of dietary fat, increasing the consumption of fruits, vegetables, and whole grain cereals, consuming smoked and charcoal-broiled foods only in moderation, and drinking alcoholic beverages only in moderation.

"Nutritional Oncology: Nutrition in Cancer Prevention, Treatment, and Survivorship presents evidence-based approaches to the study and application of nutrition in all phases of cancer including prevention, treatment, and survivorship. There is a long history of interest in the role of nutrition in cancer but only in the last 50 years has this interdisciplinary field developed scientific evidence from a combination of population studies, basic research, and clinical studies. Precision oncology, targeted therapies and immunonutrition have led to advances in cancer treatment and prevention. Highlighting insights from Precision Oncology and Precision Nutrition to improve cancer prevention, treatment and survival is the core mission of this book. The editors have over 40 years of clinical and research experience integrating science with practical advice based on available evidence for healthcare professionals while highlighting research vistas for the scientific community"-- Provided by publisher.

Intro -- Stromal Signaling in Cancer -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: The pathologic diagnosis of carcinoma in various tissues -- 1. Introduction -- 2. Breast carcinoma -- 3. Colorectal carcinoma -- 4. Lung carcinoma -- 5. Pancreatic carcinoma -- 5.1. Liver -- 6. Hepatocellular carcinoma -- 7. Prostate carcinoma -- 8. Central nervous system malignancy -- References -- Chapter Two: Predictive value of collagen in cancer -- 1. Introduction -- 2. Breast cancer -- 2.1. Prostate adenocarcinoma -- 3. Lung cancer -- 4. Hepatocellular carcinoma (liver cancer) -- 5. Colon cancer -- 6. Pancreatic cancer -- 7. Perspectives and conclusions -- Acknowledgments -- Author contributions -- References -- Chapter Three: Molecular sensors for detection of tumor-stroma crosstalk -- 1. Introduction -- 2. Force biosensors -- 2.1. The role of mechanical stimuli on tumor growth and metastasis -- 2.2. Principles of molecular force probes -- 2.3. Application of molecular force probes -- 3. Imaging reporters for single-cell kinase signaling -- 3.1. Kinase translocation reporter biosensors -- 3.2. FRET-based biosensors for studying kinase signaling -- 4. Biosensors for detection of cellular metabolic activity -- 4.1. Monitoring glucose uptake in tumors -- 4.1.1. (18)F-fluorodeoxyglucose -- 4.1.2. 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose -- 4.2. Biosensors for detecting intracellular ATP levels -- 4.2.1. PercevalHR -- 4.2.2. ATeam -- 4.2.3. BTeam -- 4.2.4. iATPSnFR -- 4.3. Biosensors for detecting intracellular glucose levels -- 4.3.1. Green Glifons -- 4.3.2. Fluorescent glucose/galactose binding protein -- 4.4. Biosensors for detecting NAD+ -- 4.5. Other metabolic sensors -- 4.5.1. Pyruvate -- 4.5.2. Lactate and 2-oxoglutarate -- 5. Detecting cell-cell interactions.

Front Cover -- Bone Cancer -- Bone Cancer: Bone Sarcomas and Bone Metastases -- From Bench to Bedside -- Copyright -- Contents -- Contributors -- Foreword I -- Foreword II -- Foreword III -- Preface -- I -- Basic Aspects of Bone Cancers -- I -- Epidemiology of Bone Cancers -- 1 -- Cancer: lessons to learn from the past -- Introduction -- Who studies cancer(s) in ancient people(s)? -- How do we recognize cancer in the past? -- What do we know about the past of cancer? a global perspective -- Documental evidence -- Bioarchaeological evidence -- Lessons from case-driven research
Lessons from population-driven research -- Limits and pitfalls of paleo-oncology -- Conclusion and perspectives -- Acknowledgments -- References -- 2 -- Epidemiology of primary bone tumors and economical aspects of bone metastases -- Incidence of primary bone tumors -- Age -- Gender -- Site distribution -- Incidence of bone tumors as a secondary event -- Racial differences in incidence of primary bone tumors -- Incidence of bone metastases -- Pathology of bone metastases -- Cost of illness -- Economic burden of bone metastasis -- Conclusions -- Acknowledgments -- References
II -- Animal Models of Bone Cancers -- 3 -- Mammalian models of bone sarcomas -- Introduction -- Models based on the inoculation of cancer cells and the implantation of tumor fragments -- Genetically engineered animal models -- Conclusion -- Acknowledgments -- References -- 4 -- In vivo models used in studies of bone metastases -- Introduction -- Models used in the studies of breast cancer bone metastases (Table 4.1) -- Xenograft models -- Intracardiac injection -- Mechanisms of bone metastasis formation -- Effects of therapies -- Intravenous/intra-arterial injection
Mechanisms of bone metastasis formation -- Effects of therapies -- Intraosseous implantation -- Mechanisms of bone metastasis formation -- Effects of therapies -- Syngeneic models -- Mechanisms of bone metastasis formation -- Effects of therapies -- In vivo models of prostate cancer bone metastases (Table 4.2) -- Xenograft models -- Intracardiac injection -- Mechanisms of bone metastasis formation -- Effects of therapies -- Intratibial implantation -- Mechanisms of metastasis -- Effects of therapies -- Orthotopic implantation -- Syngeneic models -- Modeling metastasis to/in human bone (Table 4.3)
Murine models of myeloma-induced bone disease (Table 4.4) -- Syngeneic murine models of MM -- The 5T series of MM models -- The 5T2 syngeneic model of MM -- Tumor homing, colonization, and development -- The effects of therapies -- The 5T33 syngeneic model of MM (reduce) -- Tumor homing, colonization, and development -- The effects of therapies -- The 5TGM1 syngeneic model of MM -- Tumor homing, colonization, and development -- The effects of therapies -- Transgenic models of MM -- Xenograft models of MM -- SCID-xenograft models of MM -- Tumor homing, colonization, and development

Intro -- Cancer: Oxidative Stress and Dietary Antioxidants -- Copyright -- Preface -- Contents -- Contributors -- Section A: Oxidative stress and cancer -- Chapter 1: Paraoxonases, oxidative stress, and breast cancer -- Introduction -- Functions and physiological roles of PON1 -- PON1 and cancer: Focusing on breast cancer -- PON1 signaling pathways -- PON1 polymorphisms -- Function and physiological roles of PON2 and PON3 -- PON2/3 and cancer: Focusing on breast cancer -- PON2 signaling pathways -- PON3 signaling pathways -- PON2/3 polymorphisms
The paradox: PON activities and BC development -- Concluding remarks -- Application to other cancers -- Summary points -- References -- Chapter 2: Oxidative stress and prostate cancer -- Introduction -- Causes of oxidative stress in prostate cancer -- Increased ROS production -- Altered mitochondrial bioenergetics -- Upregulation of Nox enzymes -- Upregulation of COX enzymes -- Hypoxia -- Impaired antioxidant defenses -- Altered antioxidant enzymes -- Altered transcriptional factors related to the redox balance -- Role of oxidative stress in the pathogenesis of prostate cancer
Oxidative stress in carcinogenesis and cancer progression -- Oxidative stress in castration resistance -- Oxidative stress in resistance to other therapeutics -- Prostate cancer risk factors and their links to oxidative stress -- Aging -- Genetic background (race and family history) -- Androgens -- Inflammation -- Diet -- Lifestyle -- Conclusions -- Applications to other cancers or conditions -- Summary points -- References -- Chapter 3: Oxidative stress in lung cancer -- Introduction -- Lung cancer -- Etiology of lung cancer -- Tobacco smoking -- Air pollution -- Infection and inflammation
Radon -- Genetics -- Tobacco smoking and oxidants -- Silica and oxidants -- Asbestos and oxidants -- MicroRNAs and oxidative stress -- Radon and oxidative stress -- Inflammation and oxidative stress -- Oxidative stress leads to DNA mutations and lung cancer -- Lipid and protein peroxidation -- Antioxidants and lung cancer prevention -- Conclusion -- Summary points -- References -- Chapter 4: Endogenous antioxidants in the prognosis and treatment of lung cancer -- Double-edged sword of antioxidants in cancer -- Nrf2: Transcriptional regulator of the redox balance -- Role of Nrf2 -- Nrf2 in NSCLC
Nrf2-mediated chemoresistance and therapeutic strategies -- Glutathione and thioredoxin antioxidant systems -- GSH system -- GSH system in NSCLC -- Therapeutic strategies -- Trx system -- Trx system in NSCLC -- Therapeutic strategies -- Dual targeting of the Trx and GSH systems -- Application to other cancers -- Summary points -- References -- Chapter 5: Oxidative stress in stomach cancer -- Introduction -- Oxidative stress and host cell -- Oxidative stress and H. pylori -- Host damage by oxidative stress and gastric carcinogenesis -- Oxidative stress and CD44v9-positive gastric cancer stem cells

Front Cover; Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy; Copyright; Dedication; Contents; Contributors; About the Editor; About the Series Editor; Aims and Scope for Series ""Cancer Sensitizing Agents for Chemotherapy; Preface; Chapter 1: Overview of Pancreatic Cancer Biology; Introduction; Pathogenesis and Molecular Biology; Three Biological Stages of Cancer Development; Initiation; Clonal Expansion; Oncogenesis; KRAS; Raf/Mitogen-Activated Protein Kinase (MAPK) Cascade; Phosphoinositide 3-Kinase/ATK Cascade; Nuclear Factor Kappa B Signaling Cascade
Tumor Suppressor GenesCDKN2A; TP53; SMAD4; Introduction to Local and Distant Microenvironments; Familial Pancreatic Cancers; Conclusions; References; Further Reading; Chapter 2: Chemoresistance in Pancreatic Cancer: Emphasis on Age and Gender; Introduction; Pancreatic Cancer Incidences and Prognosis: Association of Age and Gender; Chemoresistance: Association With Age and Gender; Mechanisms Associated With Chemoresistance; Factors Modulated in Various Age Groups; Conclusion; Acknowledgments; References; Chapter 3: EMT Contributes to Chemoresistance in Pancreatic Cancer; Introduction
Gemcitabine SensitivityGemcitabine and Chemoresistance; Role of Gemcitabine in Targeting Signaling Pathways; Conclusion; Acknowledgment; References; Chapter 5: Pancreatic Cancer and Possible Therapeutic Options; Introduction; Reasons Behind the Above Statistics?; Brief Outline of Treatment; Tumor-Node-Metastasis Staging and Clinical Classification; Modalities for Evaluating TNM Staging; Clinical Classification; Treatment Options for Pancreatic Adenocarcinoma; Localized Surgically Resectable Stage I and II Disease; Adjuvant Therapy; Gemcitabine and 5-Fluorouracil; Gemcitabine and S-1
Gemcitabine and CapecitabineAdjuvant Chemoradiation; Gemcitabine Plus Nab-Paclitaxel; Neoadjuvant Therapy; Adjuvant Therapy in Borderline Removable Pancreatic Carcinoma; Evidence Supporting Neoadjuvant Therapy; FOLFIRINOX as Neoadjuvant Therapy; NAC-GSL (Neoadjuvant Chemotherapy-Gemcitabine, S-1, LV); Metastatic Pancreatic Cancer: Treatment Options; Early Period; First-Line Therapies; FOLFIRINOX; PRODIGE-4/ACCORD-11 Trial; Outcomes of PRODIGE-4/ACCORD-11 Trial; Precautionary and Toxicity Reducing Strategies; Gemcitabine Plus Nab-Paclitaxel; The MPACT Trial

"Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy"--Publisher's description.

"This book highlights new principles of immune suppression that drive cancer, and offers radically new ideas about how therapy can be improved by attacking these principles. It provides an overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease"--Publisher's description.

Designed for the busy practitioner, Cancer provides succinct coverage of the assessment and treatment of a multitude of rehabilitation issues as they uniquely affect cancer patients. Broken into four sections with 66 alphabetically arranged topics, this go-to reference addresses the key concerns in cancer rehabilitation ranging from basic principles, exercise, and therapy interventions to acupuncture, massage, and end-of-life care. (www.amazon.com)

Management of Cancer in the Older Patient, by Drs. Arash Naeim, David Reuben, and Patricia Ganz, offers the help you need to effectively diagnose, refer, and manage cancer in geriatric patients. You'll see how to provide effective cancer screening; refer your patients to the right oncologist; deal with comorbidities, frailties, and other complications; navigate end-of-life issues; and much more. A templated, user-friendly format, both in print and online at www.expertconsult.com, makes it easy to find and apply the answers you need. See how to best manage geriatric cancer patients with help from leading specialists in both geriatrics and oncology Make informed decisions as to when to refer patients to specialists. Provide the supportive care your patients and their families need on issues such as such as mental health, pain, fatigue, nausea, insomnia, nutri Be prepared to help cancer survivors navigate their after-treatment care including adjuvant therapy, side effects, second cancers, quality of life, and other concerns. Offer accurate guidance on ethical issues like competency, end of life, hospice, the role of the caregiver, and more Access the complete contents online at www.expertconsult.com.

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details c.

Intro; Title page; Table of Contents; Copyright; Dedication; Contributors; Author Biographies; Preface; Acknowledgments; Chapter 1: The Origin of Chronic Diseases With Respect to Cardiovascular Disease; Abstract; 1.1 Introduction; 1.2 Causes of Chronic Diseases Such as CVD; 1.3 Unresolved and Emerging Public Health Hazards due to Genetic, Dietary, Environmental, and Lifestyle Factors; 1.4 Concluding Remarks; Chapter 2: Inflammation; Abstract; 2.1 Inflammation; 2.2 Inflammatory Mediators; 2.3 Inflammation and Disease; 2.4 Conclusions; Chapter 3: Inflammation and Cardiovascular Diseases
Abstract3.1 Interrelation Between Inflammation, Atherosclerosis, and CVD: Moving Beyond Cholesterol, Lipoproteins, and Triglycerides; 3.2 Endothelial Dysfunction and Atherosclerosis; 3.3 Blood Cells and Cells of the Immune System in Atherosclerosis and CVD; 3.4 The Interplay and Crosstalk Between Several Inflammatory Pathways and Mediators During Atherogenesis and Atherosclerosis; The Role of Cytokines, Eicosanoids, PAF, and HDL; 3.5 Conclusion; Chapter 4: The Lipid Hypothesis and the Seven Countries Study; Abstract; 4.1 Introduction; 4.2 The Understanding of Atherosclerosis Circa 1800-1930
4.3 Cholesterol4.4 Lipid Hypothesis: Origin, Development, and Prelude to the Seven Countries Study; 4.5 Ancel Keys (1904-2004); 4.6 Familial Hypercholesterolemia; 4.7 Concluding Remarks; Chapter 5: Cholesterol in Atherosclerosis and Cardiovascular Disease: The Role of Specific Dietary and Lifestyle Patterns; Abstract; 5.1 Introduction; 5.2 Mediterranean Diet Food Pyramid; 5.3 Applying the Mediterranean Diet in Non-Med Counties: Is It Feasible?; 5.4 French Paradox; 5.5 Blue Zones Concept; 5.6 Food for Thought; Chapter 6: Statins: Rationale, Mode of Action, and Side Effects; Abstract
6.1 Introduction6.2 Cholesterol and Its Function in Humans; 6.3 How Did Statins Develop?; 6.4 Statin Mechanism of Action; 6.5 Pleiotropic Effects of Statin; 6.6 Statin Side Effects; 6.7 Dosage and Side Effects: Diabetes; 6.8 Current Guidelines for Patients; 6.9 Clarity on True Benefits Versus Risks; 6.10 Critical Evaluation; 6.11 Future Perspectives: Inflammation; 6.12 Conclusion; Chapter 7: Cardiovascular Risk: Assumptions, Limitations, and Research; Abstract; 7.1 Introduction; 7.2 Evaluation of CVD Risk; 7.3 Blood Pressure; 7.4 Cardiovascular Risk Assessment
7.5 Novel and Traditional Cardiovascular Risk Factors7.6 Conclusion; Chapter 8: Diet and Cardiovascular Disease: The Mediterranean Diet; Abstract; 8.1 Introduction; 8.2 The Mediterranean Diet in Cardiovascular Disease Prevention; 8.3 Potential Mechanisms Implicated in CVD Prevention; 8.4 The Mediterranean Diet: PAF-Related Inflammatory Pathways and Metabolism; 8.5 Implementing the Mediterranean Diet Outside the Mediterranean Region; 8.6 Conclusions; Chapter 9: Nutrition Versus Statins in Primary Prevention: Where do we Stand Now?; Abstract; 9.1 Inflammation

Rapid Cardiac Care is an indispensable resource for all frontline staff working with acutely ill patients. Offering easy access to the knowledge base needed to provide rapid, safe and effective cardiac care, it is ideal for newly qualified healthcare professionals including, nurses, paramedics, cardiac technicians, junior medics, and physiotherapists. Key features include: Essential information to support the assessment of the cardiac patient including focused history taking and physical assessment, rhythm interpretation and 12-lead ECG assessment Practical guidance on how to care for patients with cardiac emergencies, including acute coronary syndromes, arrhythmias, heart failure and cardiac arrest A quick reference A-Z section that explores a wide range of conditions affecting the heart, each with a comprehensive overview of patient presentation and strategies to guide patient assessment and management Diagrams and images are provided to facilitate learning

The management of hypertension varies considerably from clinician to clinician. This pocketbook is a concise and evidence-based summary of current understanding and practice, including the most up-to-date guidance from national bodies and their recommendations for hypertension care. An essential tool for everyday use in managing hypertension, this book covers the different phases of investigation and definitive management, and aids clinical decision-making by collating all the relevant information and guidance in one easily accessible place.

Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health compiles the most up-to-date research discoveries to provide a timely and scientific rationale for the significant impact of a fiber rich diet for the prevention of heart disease. By focusing on the science behind how fiber, both soluble and insoluble can lead to lower rates of heart disease, this important reference will educate researchers, cardiologists, medical providers and students on how to improve patients'hearts via a fiber rich diet. Coverage includes the known mechanisms of how fiber works to reduce insulin resistance, control weight, reduce cholesterol by binding with bile, maintain stable glucose levels and influence gut microflora. Explains how fiber affects cardiovascular disease through the influence on insulin resistance, reduction of cholesterol, change in gut microflora and in weight controlProvides thorough coverage of the effect of fiber on arrhythmias and valvular abnormalitiesIncludes information on the indirect relationship between constipation and heart disease

A comprehensive and practical guide to dementia, this book is essential reading for anyone who has a friend or relative with the condition. This updated edition reflects new guidance on approaches to supporting people with dementia, focussing especially on the UK, and includes quotes from people with dementia as well as from family carers. The book explores each stage of the journey people with dementia face and explains how it affects the person, as well as those around them both at home and in residential settings. It shows how best to offer support and where to get professional and informal assistance. Focussing on the progressive nature of dementia and the issues that can arise as a result, it gives practical advice that can help to ensure the best possible quality of life both for the person with dementia and the people around them.

Diet and Nutrition in Dementia and Cognitive Decline offers researchers and clinicians a single authoritative source which outlines the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes. In a cross-disciplinary field like dementia research and practice, clinicians and researchers need a comprehensive resource which will quickly help them identify a range of nutritional components and how they affect cognitive decline and the development of dementia. While the focus is on clinical applications, the book also features landmark.

This practical guide clearly shows each stage in the management of a patient with dementia. It covers the complex issues surrounding dementia such as spouses and families, access to appropriate care, legal and ethical concerns, planning for the future and "living well" and includes the decision making process on initiating treatment and guidance on how best to access the available services.

"Get practical guidance from renowned dermatologist Dr. Thomas Habif and his expert team of co-authors in this user-friendly, focused text. Written specifically for the non-specialist, this easy-to-follow reference offers precisely the diagnostic and treatment information you need to quickly identify the 250 skin disorders you're most likely to see. It's an ideal resource for any medical practitioner who'd rather treat than refer patients with skin disease, as well as an excellent review for board preparation"--Publisher's description.

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function. Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes. Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression. Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes.

This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system. * Offers a unique emphasis on the neurological manifestations of diabetes * Provides thorough coverage of the clinical, experimental, mechanistic, therapeutic, peripheral, and central aspects of diabetic neuropathy.

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and i.

Intro -- Diabetes and Retinopathy -- Copyright -- Contents -- Contributors -- Chapter 1: Complementary capabilities of photoacoustic imaging to existing optical ocular imaging techniques -- References -- Chapter 2: Intraretinal fluid map generation in optical coherence tomography images -- 1. Introduction -- 2. Optical coherence tomography: Background and significance -- 3. The classical segmentation approach -- 4. Fluid identification by means of a regional analysis -- 4.1. ROI extraction -- 4.2. Image sampling -- 4.3. Classification -- 4.4. Binary map creation -- 4.5. Color map creation
5. Discussion and conclusions -- Acknowledgments -- References -- Chapter 3: Fully automated identification and clinical classification of macular edema using optical coherence tomography ... -- 1. Background and significance -- 2. Computational identification and characterization of the MEs -- 2.1. Region of interest delimitation -- 2.2. Identification of the different types of macular edema -- 3. Results and discussion -- 4. Conclusions -- Acknowledgments -- References -- Chapter 4: Optimal surface segmentation with subvoxel accuracy in spectral domain optical coherence tomography images
1. Introduction -- 2. Methods -- 2.1. Problem formulation and energy function -- 2.1.1. Original formulation in regularly sampled space -- 2.1.2. Formulation in irregularly sampled space to achieve subvoxel accuracy -- 2.2. Graph construction -- 2.2.1. Intracolumn edges -- 2.2.2. Intercolumn edges -- 2.2.3. Intersurface edges -- 2.3. Surface recovery from minimum s-t cut -- 3. Experimental methods -- 3.1. Data -- 3.2. Workflow -- 3.2.1. Experiment for subvoxel accuracy -- 3.2.2. Experiment for super-resolution accuracy -- 3.2.3. Cost function design -- 3.2.4. Gradient vector flow
3.2.5. Parameter setting -- 4. Results -- 4.1. Results for subvoxel accuracy -- 4.2. Results for super-resolution accuracy -- 5. Discussion and conclusions -- References -- Chapter 5: Analysis of optical coherence tomography images using deep convolutional neural network for maculopathy grading -- 1. Introduction -- 1.1. Macular edema -- 1.2. Age-related macular degeneration -- 1.3. Central serous chorioretinopathy -- 2. Retinal imaging modalities -- 2.1. Optical coherence tomography -- 3. Dataset description -- 4. TU-Net: A deep CNN architecture for maculopathy grading -- 4.1. Preprocessing
4.2. Proposed TU-Net architecture -- 5. Results and discussion -- 6. Conclusion -- References -- Chapter 6: Segmentation of retinal layers from OCT scans -- 1. Introduction -- 2. Method -- 2.1. Joint MGRF-based macula: Centred image segmentation -- 2.1.1. Shape model Psp(m) -- 2.1.2. Appearance model -- 2.2. 3D retinal layers segmentation -- 3. Experimental results -- 4. Conclusion -- References -- Chapter 7: Low-complexity computer-aided diagnosis for diabetic retinopathy -- 1. Introduction -- 2. Related work -- 3. Low-complexity CNN for diabetic retinopathy

Intensive diabetes management is the process by which blood glucose levels are closely controlled using multiple daily insulin injections or an insulin pump. People who use this method of diabetes management must be closely aligned with their health care team and highly motivated because it not only requires close scrutiny of blood glucose levels, but also constant monitoring of food intake and medication dosage, among other things. Although difficult to maintain, intensive diabetes management has proven very effective and is now the rule, rather than the exception, in diabetes care. Virtually all patients with diabetes—type 1 or type 2—can improve their glycemic control and overall health through intensive diabetes management. Intensive Diabetes Management is geared toward the health care practitioner who wants to implement this method in his or her patients. It emphasizes a team approach to patient care and offers guidance in helping patients move toward treatment goals appropriate for their individual skills and medical condition. Individual sections address all of the key topics in intensive diabetes management, including rationale/physiological Basis, team approach, education, pyschosocial issues patient selection/goals of therapy, insulin regimens, insulin pump therapy, monitoring, and nutrition management. This new edition is updated to cover the latest advances in medical research. New insights into diabetes and how they impact this particular treatment are covered. In addition, the data, guidelines, and procedures have been revised to reflect that newest positions of the American Diabetes Association's standards of care.

Physical movement has a positive effect on physical fitness, morbidity, and mortality in individuals with diabetes. Although exercise has long been considered a cornerstone of diabetes management, many health care providers fail to prescribe it. In addition, many fitness professionals may be unaware of the complexities of including physical activity in the management of diabetes. Giving patients or clients a full exercise prescription that take other chronic conditions commonly accompanying diabetes into account may be too time-consuming for or beyond the expertise of many health care and fitness professionals. The purpose of this book is to cover the recommended types and quantities of physical activities that can and should be undertaken by all individuals with any type of diabetes, along with precautions related to medication use and diabetes-related health complications. Medications used to control diabetes should augment lifestyle improvements like increased daily physical activity rather than replace them. Up until now, professional books with exercise information and prescriptions were not timely or interactive enough to easily provide busy professionals with access to the latest recommendations for each unique patient. However, simply instructing patients to “exercise more" is frequently not motivating or informative enough to get them regularly or safely active. This book is changing all that with its up-to-date and easy-to-prescribe exercise and physical activity recommendations and relevant case studies. Read and learn to quickly prescribe effective and appropriate exercise to everyone.

Diabetes Management in Long-Term Settings is a clinical guide for the treatment of elderly patients with diabetes. With the number of older adults growing exponentially and with a growing percentage of this group facing diabetic and prediabetic conditions, Diabetes Management in Long-Term Settings will help physicians, nurses, pharmacists, and administrators develop effective programs to care for this growing population. It is a practical clinical guide outlining the protocols of geriatric diabetes care and will be a sought-after reference for all clinicians.

Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. Features Highlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes Features emerging therapeutic approaches for management of obesity and diabetes Discusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome them The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes.

Today, most doctors, dietitians, and even diabetes specialists consider type 2 diabetes to be a chronic and progressive disease--a life sentence with no possibility of parole. But the truth, as Dr. Fung reveals in this paradigm-shifting book, is that type 2 diabetes is reversible. Writing with clear, persuasive language, he explains why conventional treatments that rely on insulin or other blood-glucose-lowering drugs can actually exacerbate the problem, leading to significant weight gain and even heart disease. The only way to treat type 2 diabetes effectively, he argues, is proper dieting and intermittent fasting--not medication.

This groundbreaking new text explains and documents the scientific basis of chronic pain in Joint Hypermobility Syndrome (JHS) and other heritable disorders of connective tissue from the physiological, epidemiological, genetic and clinical viewpoints. It asks the reader to consider the possibility of JHS, identify it clinically, understand its co-morbidities, including interdependencies with Fibromyalgia and Chronic Fatigue Syndrome, while managing the condition appropriately. Hypermobility, Fibromyalgia and Chronic Pain takes a multi-specialty and multidisciplinary approach to understanding JHS and its management, drawing together expertise from a broad group of internationally-recognized authors. The book is split into two sections. Section 1 deals with the clinical manifestations of JHS and Fibromyalgia, their epidemiology and pathophysiology. Section 2 covers clinical management. Here the reader will find chapters covering pharmacotherapeutics, psychotherapy and physical therapies that address the needs of patients from childhood to adulthood.

Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities is a unique reference work-the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, only five percent are properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. (www.amazon.com)

Introduction to gluten spectrum disorders -- Celiac disease -- Gluten sensitivity -- Wheat allergy -- Diagnosis -- Treatment -- Psychosocial aspects of gluten spectrum disorders -- Difficult cases

Front Cover; The Changing Era of Diseases; The Changing Era of Diseases; Copyright; Contents; Preface; Overview; 1. Can We Live in a Disease-Free World?; 2. Pandemic of Chronic Diseases and the Late Chronic Diseases; 3. Changing View of Disease; 4. What Next After the End of "the Era of Diseases"?; 5. Composition of This Book; 1 -- From the Origin of Disease to Pandemic Infectious Diseases; 1.1 The Emergence of Diseases; Humankind undergoes physical and intellectual development; Hunter-gatherers suffered from infectious diseases but never from communicable diseases
Civilization gave birth to diseases; Livestock breeding changes the disease pattern of humankind; Is disease a punishment from god?; 1.2 Humankind Begins to See Disease Through the Eyes of Reason; Reason leaps forward; Hippocrates brings down disease from god's domain to the human domain; Rising to the center of western medicine through anatomical knowledge; Oriental medicine took a different path from western medicine; 1.3 Epidemics Changed History; Conditions ripe for epidemics of infectious disease; Smallpox brought the fear of epidemics
The black death ends feudalism and makes powerful nations appear Influence of epidemics in the history of the west and the east; Medicine equipped with the potential to develop into a science; 1.4 Biomedical View of Diseases as the Basis of Modern Medicine; The industrial revolution spreads tuberculosis and cholera; Emergence of modern medicine, which assumes the specific cause of a specific disease; Disease-centered instead of patient-centered medicine; Western medicine replaces traditional oriental medicine in the east; 2 -- The Age of Chronic and Late Chronic Diseases: A New View of Diseases
2.1 Humankind Enters the Age of Chronic Diseases; The age of epidemics finally draws to an end; Chronic disease accounts for two-thirds of all deaths in the 21st century; Genetic mutation is not the main cause of a chronic disease; Mankind's changing living environment causes chronic diseases; Age of chronic diseases: from the disease-centered approach to the people-centered approach; 2.2 The Age of Late Chronic Diseases Is Looming; Fast-changing aspects of disease; Chronic diseases decrease in developed countries and increase in underdeveloped countries and among the lower classes
Can the advancement of medicine end chronic diseases? Another disease emerges following chronic diseases; 2.3 Disease Occurs When Harmony and Balance of the System Are Breached; The human body is composed of complex systems; Approaching disease with a new view; Avoid the fallacy of exaggeration and oversimplification; Decoding the black box for the identification of the cause; 2.4 A Step Closer to the Closure of Disease Era; Identifying the complex systems affecting disease; The flow of time affects the development of a disease; Systems medicine approach is needed

The increase of immigrant population in developed countries (mainly in Europe and North America) together with an important increase of international travel worldwide are the two most important causes that have contributed to the introduction and diagnosis of imported/tropical infectious diseases in these countries. These factors have had an important impact in developed countries in both social and economic aspects. Imported Infectious Diseases focuses not only on describing the infections, but also in evaluating the current epidemiology, the economic and social impact and the possibility to apply immunization measures and vaccines. The main purpose of this book is to give an overview of the current most important and frequent imported infectious diseases in developed countries. The first chapter informs about the medical services that are being offered to the immigrants in the main developed countries depending on the legal situation. Following chapters describe the main surveillance systems for these kinds of diseases, mainly in Europe and North America. Finally, remaining chapters contain sections on epidemiology, pathogenesis, clinical features, diagnosis, treatment and prevention.

This complete guide to treating patients with sacroiliac joint dysfunction, or piriformis syndrome, combines multiple techniques—rather than the usual single approach—to get quicker and more resilient results. Focusing on the practical application of skills acquired in twenty years of treating elite athletes, Paula Clayton provides a comprehensive guide to the latest discussions of the therapeutic handling of fascial tissue, dry needling, instrument-assisted soft-tissue manipulation, and dynamic taping. Presenting material formerly unavailable in one volume, this book provides evidence-based information on fundamental principles that enable practitioners to map approaches to dysfunction and injury before attempting hands-on treatments. Superbly designed for ease of use and supported with full-color illustrations that clarify and complement the text, this book puts decades of experience and research at readers' fingertips, expanding their ability to both improve their practice and educate their patients.

This groundbreaking new text explains and documents the scientific basis of chronic pain in Joint Hypermobility Syndrome (JHS) and other heritable disorders of connective tissue from the physiological, epidemiological, genetic and clinical viewpoints. It asks the reader to consider the possibility of JHS, identify it clinically, understand its co-morbidities, including interdependencies with Fibromyalgia and Chronic Fatigue Syndrome, while managing the condition appropriately. Hypermobility, Fibromyalgia and Chronic Pain takes a multi-specialty and multidisciplinary approach to understanding JHS and its management, drawing together expertise from a broad group of internationally-recognized authors. The book is split into two sections. Section 1 deals with the clinical manifestations of JHS and Fibromyalgia, their epidemiology and pathophysiology. Section 2 covers clinical management. Here the reader will find chapters covering pharmacotherapeutics, psychotherapy and physical therapies that address the needs of patients from childhood to adulthood.

This practical guide provides explanations of the techniques for measuring both joint range of motion and muscle length testing. In addition to the comprehensive coverage of the measurement techniques, this text provides valuable information on measuring norms and a critical review on the reliability of specific tests. Readers will find the most complete information available to date on measurement of joint ROM of the spine, as well as muscle length of the upper and lower extremities. (Publisher's Description).

Comprised exclusively of clinical cases presenting injuries to and management of the rotator cuff, this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly manage the various kinds of cuff injury they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome, literature review and clinical pearls and pitfalls. Cases included illustrate different management strategies for rotator cuff surgery, including arthroscopic repair for tendonitis and tears, open and mini-open repair for severe tears, latissimus dorsi and pectoralis tendon transfer, arthroscopic debridement, hemiarthroplasty and total reverse arthroplasty, biological augmentation, and revision repair after retear and infection. Pragmatic and reader-friendly, Rotator Cuff Injuries: A Clinic al Casebook is an excellent resource for orthopedic surgeons and sports medicine specialists confronted with both common and complex injuries to the rotator cuff.

Psychosocial Aspects of Chronic Kidney Disease: Exploring the Impact of CKD, Dialysis, and Transplantation on Patients provides an overview of the emotional and psychological challenges faced by people with renal disease. This book outlines the epidemiology and treatment of the psychosocial factors affecting them. The sections in the book cover psychiatric illness in the earlier and middle stages of chronic kidney disease, end-stage renal disease treated with dialysis, and renal transplantation. The book concludes with a section on special considerations, delving into topics such as treating children and adolescents, quality of life, caregiver burden, challenges in psychosocial research in kidney disease, and future directions for intervention.

"Chronic Renal Disease comprehensively investigates the physiology, pathophysiology, treatment, and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD while excluding coverage of dialysis or transplantation, which are both well detailed in other textbooks and references. Chapters in the basic science sections are devoted to the scientific underpinnings of the development and progression of CKD, including consideration of different etiologic factors. Chapters in the treatment and management sections are geared towards the most common problems faced by nephrologists in the management of CKD. Each chapter relates specific illnesses to the CKD framework instead of covering only the specific illness. Readers will learn, for example, how the management of CKD in a patient with diabetic nephropathy differs from that of other CKD patients. Chapters indicate which unique complications the reader needs to be aware of when treating a specific patient or disease"--Publisher's description.

Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations. Presents a comprehensive account of both traditional and non-traditional risk factors for kidney diseaseExplores the mechanisms by which poverty increases the burden of kidney disease in these populations, barriers to access to renal health care, including renal replacement therapies, organ donation, and organ commercializationOffers the latest perspectives on outcomes in renal replacement therapies as well as prevention strategies.

Local anaesthetics -- Applications of local anaesthetics -- Patient suitability for local anaesthetic -- Calculating maximum safe doses -- Complications of peripheral nerve blocks -- Nerve stimulators -- The basics -- Basic local anaesthetic techniques -- Advanced local anaesthetic techniques -- Corticosteroid injection therapy -- Common foot and ankle conditions: joint injections -- Common foot and ankle conditions: soft tissue injections -- Other injection therapies.

"The physical examination of the foot and ankle can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user-friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the foot and ankle? Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple by Drs. Shepard Hurwitz and Selene Parekh answers these questions. Written by experts, this easy-to-carry book provides a quick and thorough review of the most common pathologic foot and ankle conditions, techniques for diagnosis, as well as the appropriate treatment for each condition. Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple contains clear photographic demonstrations, tables, sidebars, and charts throughout its pages, allowing a thorough and concise examination of the foot and ankle. A glance at some of what is covered inside: * Physical Examination * Basics and specific tests of the foot and ankle * General Imaging * Basic interpretation of common imaging modalities of the foot and ankle * Common Conditions * Bunions, toe deformities, Achilles pathology and posterior calcaneal pain, fractures, plantar fasciitis and plantar heel pain, and more Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple contains essential information to successfully take a complex subject, and bring it to a level that will be welcomed by orthopedic residents, faculty, physical therapists, athletic trainers, medical students interested in musculoskeletal health careers, and other health care providers. "--Provided by publisher.

Winner of the Medical Journalists' Association's Tony Thistlethwaite Award A Finalist for the Royal Society Winton Prize for Science Books Recipient of the International OCD Foundation's Illumination Award An intimate look at the power of intrusive thoughts, how our brains can turn against us, and living with obsessive compulsive disorder What might lead a schoolgirl to eat a wall of her house, piece by piece, or a man to die beneath an avalanche of household junk that he and his brother have compulsively hoarded? At what point does a harmless idea, a snowflake in a clear summer sky, become a blinding blizzard of unwanted thoughts? David Adam—an editor at Nature and an accomplished science writer—has suffered from obsessive-compulsive disorder for twenty years, and The Man Who Couldn't Stop is his unflinchingly honest attempt to understand the condition and his experiences. In this riveting and intimate blend of science, history, and memoir, Adam explores the weird thoughts that exist within every mind and explains how they drive millions of us toward obsession and compulsion. Told with fierce clarity, humor, and urgent lyricism, The Man Who Couldn't Stop is a haunting story of a personal nightmare that shines a light into the darkest corners of our minds.

Isn't it time you stopped walking on eggshells? Learn how with this fully revised and updated third edition of a self-help classic—now with more than one million copies sold! Do you feel manipulated, controlled, or lied to? Are you the focus of intense, violent, and irrational rages? Do you feel you are 'walking on eggshells' to avoid the next confrontation? If the answer is 'yes,' someone you care about may have borderline personality disorder (BPD)—a mood disorder that causes negative self-image, emotional instability, and difficulty with interpersonal relationships. Stop Walking on Eggshells has already helped more than a million people with friends and family members suffering from BPD understand this difficult disorder, set boundaries, and help their loved ones stop relying on dangerous BPD behaviors. This fully revised third edition has been updated with the very latest BPD research on comorbidity, extensive new information about narcissistic personality disorder (NPD), the effectiveness of schema therapy, and coping and communication skills you can use to stabilize your relationship with the BPD or NPD sufferer in your life. This compassionate guide will enable you to: Make sense out of the chaos Stand up for yourself and assert your needs Defuse arguments and conflicts Protect yourself and others from violent behavior If you're ready to bring peace and stability back into your life, this time-tested guide will show you how, one confident step at a time.

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

An unapologetic exploration of the Black mental health crisis—and a comprehensive road map to getting the care you deserve in an unequal system. We can't deny it any longer: there is a Black mental health crisis in our world today. Black people die at disproportionately high rates due to chronic illness, suffer from poverty, under-education, and the effects of racism. This book is an exploration of Black mental health in today's world, the forces that have undermined mental health progress for African Americans, and what needs to happen for African Americans to heal psychological distress, find community, and undo years of stigma and marginalization in order to access effective mental health care. In The Unapologetic Guide to Black Mental Health , psychologist and African American mental health expert Rheeda Walker offers important information on the mental health crisis in the Black community, how to combat stigma, spot potential mental illness, how to practice emotional wellness, and how to get the best care possible in system steeped in racial bias. This breakthrough book will help you: Recognize mental and emotional health problems Understand the myriad ways in which these problems impact overall health and quality of life and relationships Develop psychological tools to neutralize ongoing stressors and live more fully Navigate a mental health care system that is unequal It's past time to take Black mental health seriously. Whether you suffer yourself, have a loved one who needs help, or are a mental health professional working with the Black community, this book is an essential and much-needed resource.

Psychosis can be associated with a variety of mental health problems, including schizophrenia, severe depression, bipolar disorder, anxiety, and post-traumatic stress disorders. While traditional treatments for psychosis have emphasized medication-based strategies, evidence now suggests that individuals affected by psychosis can greatly benefit from psychotherapy. Treating Psychosis is an evidence-based treatment guide for mental health professionals working with individuals affected by psychosis. Using a cognitive behavioral therapy (CBT) approach that incorporates acceptance and commitment therapy (ACT), compassion-focused therapy (CFT) and mindfulness approaches, this book is invaluable in helping clinicians develop effective treatment for clients affected by psychosis. The guide provides session-by-session clinical interventions for use in individual or group treatment on an inpatient, outpatient, or community basis. The book features 40 reproducible clinical practice forms and a companion website with additional downloadable clinical forms and tools, guided exercises, case examples, and resources. The therapeutic approaches presented are rooted in theory and research, and informed by extensive clinical experience working with client populations affected by psychosis. The approaches outlined in this book offer clinicians and clients the opportunity to partner in developing therapeutic strategies for problematic symptoms to enable those affected by psychosis to work toward valued goals and ultimately live more meaningful lives. This guide emphasizes a compassionate, de-stigmatizing approach that integrates empowering and strengths-oriented methods that place the client's values and goals at the center of any therapeutic intervention.

http://mobius.overdrive.com/media/989012

Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of treatment-resistant mood disorders and reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and interested primary care physicians.

Part of the Oxford Psychiatry Library of pocketbooks, this user-friendly and practical guide will outline the diagnosis, evaluation and treatment of patients with schizophrenia. Co-authored by two global experts on the management of patients with psychosis, this pocketbook will serve as a useful guide for psychiatrists, trainees, psychiatric specialist nurses, and interested general practitioners. Schizophrenia is one of the most disabling mental illnesses and is also highly prevalent, occurring in approximately 1% of the population and affecting both men and women equally. The disorder has a typical onset of between 15 and 35 years of age and is characterised by impairments in reality, most commonly hallucinations and delusions. It is a highly complex condition and is often confused with other mental disorders such as bipolar disorder. This new edition will cover new DSM-5 diagnostic criteria and to reflect new data and include new longitudinal studies on psychiatric and medical co-morbidity, Genetic and environmental factors, new drug therapies, adherence and the role of depots, new advances in psychosocial therapies (CBT,ACT, & cognitive remediation) and includes an updated and expanded appendix.

Providing clinicians and patients with the latest developments in research, this new edition is a succinct and practical introduction to the diagnosis, evaluation and management of OCD and other related disorders. Part of the Oxford Psychiatry Library series, this pocketbook includes individual chapters on the phenomenology, pathogenesis, pharmacotherapy and psychotherapy of OCD and other related disorders, and features fully updated content and research. The book also includes a helpful resources chapter, and an Appendix with summaries of the major rating scales used to assess patients with OCD, which will be of use to both clinicians and patients. Obsessive-compulsive disorder (OCD) and Obsessive-compulsive-related disorders (OCRDs) are anxiety disorders characterized by obsessions and compulsions, and varying degrees of anxiety and depression. OCRDs are considered to be one of the most disabling of psychiatric disorders and they present a tremendous economic and social burden, both for the affected individual, their family, and for society at large. In contrast to other psychiatric conditions of a comparable or lesser prevalence and patient burden, relatively little is understood about the aetiology, and cognitive effects of OCRDs.

A Companion to the Classification of Mental Disorders provides essential reading as a background and supplement to both the recently produced DSM-5 and the forthcoming ICD-11. It focuses on the processes of classification and diagnosis, and the uses for these classifications. The book emphasises the dangers of regarding any current psychiatric classification as true or complete, in view of the present partial state of knowledge about the causes and mechanisms of most mental and behavioural disorders. This book is unique in containing a number of chapters that give a brief history of the cooperative efforts and projects necessary for the production of internationally agreed psychiatric classifications. The discussion begins in 1965 with the US/UK Diagnostic study, the preparations for ICD-8 with its first international glossary, and the International Pilot Study of Schizophrenia, designed and coordinated by the World Health Organization. While recognizing the importance of the innovations of the DSM series of classifications of the American Psychiatric Association, the book also takes a truly international perspective. The expert authors are well placed to do this, having been personally involved in many of the collaborative studies and developments discussed. A Companion to the Classification of Mental Disorders is an illustration of how much international collaborative work has been necessary over several decades to produce the currently agreed classifications. There is still a long way to go, but a start has been made.

Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions. Appendices include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders.

This book is a practical manual for clinical practitioners seeking to take an interdisciplinary and multidisciplinary approach to the diagnosis and management of functional movement disorder (FMD). It discusses case vignettes, reviews the diagnostic approach, provides an update on available treatments, highlights clinical pearls and details references for further reading. Organized into three parts, the book begins with a framework for conceptualizing FMD - including its historical context, the biopsychosocial model and an integrated neurologic-psychiatric perspective towards overcoming mind-body dualism. Part II then provides a comprehensive overview of different FMD presentations including tremor, dystonia, gait disorders, and limb weakness, as well as common non-motor issues such as pain and cognitive symptoms. The book concludes with chapters on updated practices in delivering the diagnosis, working with patients and care partners to achieve shared understanding of a complex condition, as well as an overview of evidence-based and evolving treatments. Supplemented with high-quality patient videos, Functional Movement Disorder is written for practicing neurologists, psychiatrists, psychologists, allied mental health professionals, and rehabilitation experts with an interest in learning more about diagnosis and management of FMD.

The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorde.

Back Pain: a movement problem is a practical manual to assist all students and clinicians concerned with the evaluation, diagnosis and management of the movement related problems seen in those with spinal pain disorders. It offers an integrative model of posturo-movement dysfunction which describes the more commonly observed features and related key patterns of altered control. This serves as a framework, guiding the practitioner's assessment of the individual patient. Key features: 1. The book explores motor control and functional movement, its development, and explores how and why it is altered in people with back pain. 2. It integrates contemporary science with the insights and experience of extensive clinical practice. 3. The book maps the more common clinical patterns of presentation in those with spinal pain and related disorders. 4. It provides a simple clinical classification system for back pain. 5. Abundantly illustrated to present concepts and to illustrate the difference between so called normal and dysfunctional presentations. 6. Written by a practitioner for practitioners.

Experts in the field, Drs. Singer, Mink, Gilbert, and Jankovic, fill the gap in the market by offering the only comprehensive text devoted solely to the diagnoses and treatment of all pediatric movement disorders. Discussions of common and rare disorders such as movements that occur in sleep and psychogenic movement disorders and the latest advances and developments in medications keep you apprised of today₂s best practices. Each chapter is accessible, illustrated, stylistically uniform, and carefully referenced, making it easy to access the information you need. This brand-new reference is the ideal resource for the seasoned specialist as well as the non-expert clinician. Best of all, Expert Consult functionality gives you convenient access to the full text online - fully searchable, a downloadable image library, and enhanced visual guidance with narrated, diagnostic videos at expertconsult.com. ₅ Includes online access to the complete contents of the book, fully searchable, including all of the book₂s illustrations, 58 narrated videos of actual patients and their disorders, and abstracts to Medline at expertconsult.com ₅ Discusses neurobiology, classification, diagnostic evaluation, and treatment, making this a one-stop-shop for all you need to know to diagnose and treat any child with any movement disorder.

"The book presents a common sense approach to interpreting and applying existing clinical knowledge and new research to help clinicians make sense of the complex phenomena of acute and chronic post-traumatic musculoskeletal pain. Built upon the Assess, Predict, Treat framework, the book offers a method to help clinicians better understand their patients pain, presents evidence-based decision tools to predict natural and clinical course of common conditions such as neck and low back pain, and then synthesizes that information into a logical integrated treatment approach that respects the individuality of the patient, the experiences of the clinician, and the value of evidence-informed practice. Written by two leaders in the field of post-traumatic pain and recovery, the book provides a valuable framework to facilitate novice clinicians in their transition towards experts, and helps mid- and late-stage clinicians better interpret, synthesize, and discuss complex information on pain with the goal of optimised outcomes for patients"--Publisher's description.

The proliferation of special tests used in musculoskeletal examination has left the clinician with a vast array of physical tests at their disposal. Special Tests in Musculoskeletal Examination is a handy one-stop guide with over 150 peripheral tests. The clinical context and evidence base is thoroughly explored and the addition of clinical tips and expert opinion will enable the clinician to select the most appropriate tests and interpret the results meaningfully. Step-by-step description for each test, Clear photographic illustrations, 'At a glance' presentation of the background evidence, Detailed clinical context Comprehensive referencing of orthopaedic special tests, Clinical tips.

Packed with illustrated treatment techniques, Trigger Point Therapy for Low Back Pain offers effective strategies beginners can practice at home and detailed hands-on protocols health care practitioners can use while working with patients. Find out which of eleven muscles could be causing back pain, then learn specific trigger point treatments and correct underlying perpetuating factors to immediately relieve soreness and tension in these muscles. If you're ready to try a targeted approach to eliminating back pain, this manual will provide you with all the information you need to get started and end low back discomfort once and for all. (http://www.amazon.com)

Chronic pain has become an epidemic in North America, yet our current health care system is ill equipped for treating sufferers. An expert in both conventional and holistic medicine, Dr. Heather Tick has spent twenty-five years treating patients for whom "all else has failed." Based on her experience, Holistic Pain Relief offers practical guidance to anyone with pain. It includes easy-to-implement solutions for effective and permanent pain relief and also offers help to those with chronic conditions who feel confused, worried, or hopeless. Dr. Tick presents a new way of looking at pain with a focus on health. By helping you make informed choices about physical, emotional, and spiritual living, Holistic Pain Relief offers possibilities for recovery and information on a wide range of treatment and prevention options, including acupuncture, chiropractic techniques, intramuscular stimulation, dietary supplements, medication, nutrition, and exercise. The result is a realistic — and inspiring — prescription for pain-free living.

Rate your pain on a scale of one℗¡to ten. What about on a scale of spicy to citrus? Is it more like a lava lamp or a mosaic? Pain, though a universal element of human experience, is dimly understood and sometimes barely managed. Pain Woman Takes Your Keys, and Other Essays from a Nervous System is a collection of literary and experimental essays about living with chronic pain. Sonya Huber moves away from a linear narrative to step through the doorway into pain itself, into that strange, unbounded reality. Although the essays are personal in nature, this collection is not a record of the author's specific condition but an exploration that transcends pain's airless and constraining world and focuses on its edges from wild and widely ranging angles. Huber addresses the nature and experience of invisible disability, including the challenges of gender bias in our health care system, the search for effective treatment options, and the difficulty of articulating chronic pain. She makes pain a lens of inquiry and lyricism, finds its humor and complexity, describes its irascible character, and explores its temperature, taste, and even its beauty.

Noted pain management authority Steven D. Waldman, MD, JD, and Robert Campbell, MD, a well-respected radiologist at Royal Liverpool Hospital in the UK, have combined their expertise to bring you Imaging of Pain. This first-of-its-kind reference helps you select the most appropriate imaging studies to evaluate more than 200 pain conditions so you can implement the most effective management approaches. You'll gain a clear understanding of how and when to use a given modality for a particular pain disorder, whether it involves bone, soft tissue, or the spinal cord. At expertconsult.com you'll access the complete contents online, fully searchable, with links to Medline and PubMed abstracts, for rapid, easy consultation from any computer. Access the fully searchable text online at expertconsult.com. Get the most definitive guidance available from leading authorities Drs. Waldman and Campbell. Know how and when to use each modality to confirm or deny a diagnosis for more than 200 pain conditions in all body regions. Provide the most effective pain relief by accurately identifying its underlying source. Find the information you need quickly thanks to a consistent, high-yield format.

The first of its kind, Neck and Arm Pain Syndromes is a comprehensive evidence- and clinical-based book, covering research-based diagnosis, prognosis and management of neuromusculoskeletal pathologies and dysfunctions of the upper quadrant, including joint, muscle, myofascial and neural tissue approaches. It uniquely addresses the expanding role of the various health care professions which require increased knowledge and skills in screening for contra-indications and recognizing the need for medical-surgical referral. Neck and Arm Pain Syndromes also stresses the integration of experiential knowledge and a pathophysiologic rationale with current best evidence. The only one-stop guide for examination and treatment of the upper quadrant supported by accurate scientific and clinical-based data acknowledges the expanding direct access role of the various health professions both at the entry-level and postgraduate level addresses concerns among clinicians that research is overemphasized at the expense of experiential knowledge and pathophysiologic rationale multiple-contributed by expert clinicians and researchers with an international outlook covers diagnosis, prognosis and conservative treatment of the most commonly seen pain syndromes in clinical practice over 800 illustrations demonstrating examination procedures and techniques.

A very brief history of pain medicine -- Definitions and epidemiology -- Anatomy and physiology of pain -- Evaluation and measurement of pain -- History and exam for spine-related pain -- Role of lab tests and imaging in the evaluation of pain -- Psychological and functional evaluation -- Goals of treatment, multidisciplinary care, disability -- Rehabilitation in pain management -- Common non-opioid pain medications -- Common opioid medications -- Patient controlled anesthesia (PCA) -- Injection agents -- Selected peripheral nerve blocks -- Spinal interventional procedures -- Complementary and alternative medicine (CAM) -- Headache -- Neuropathic pain -- Fibromyalgia and myofascial pain -- Complex regional pain syndrome -- Chronic non-malignant pain and substance abuse -- Cancer pain -- Ultrasound guided injections -- Emergencies.

A diagnosis of Parkinson's disease is as disorienting as it is devastating. The Complete Guide for People With Parkinson's Disease and Their Loved Ones helps make sense of what comes next and what can be done, not just for those suffering from the disease but for their family and friends as well. A trained nurse and primary caregiver for her mother, who was diagnosed with Parkinson's disease in 1991, Lianna Marie draws upon over twenty years of education, research, and direct experience. Written in straightforward and easily accessible language, this essential guide aims to help patients better understand their role in their treatment so that they may continue to lead happy and hopeful lives. Topics covered include nutrition and exercise, alternative and complementary therapies, medication and treatment, and what caregivers can do to help. Written by an international expert on Parkinson's who has confronted the disease firsthand, The Complete Guide serves as the go-to book for comprehensive, easy-to-understand information for all Parkinson's patients and their loved ones.

Front Cover; BALANCE DYSFUNCTION IN PARKINSON'S DISEASE; BALANCE DYSFUNCTION IN PARKINSON'S DISEASE: BASIC MECHANISMS TO CLINICAL MANAGEMENT; Copyright; Dedication; Contents; About the authors; Acknowledgments; Introduction; References; 1 -- How is balance controlled by the nervous system?; What is balance control?; B. What are the critical properties of balance control?; What are the main balance domains to assess?; Standing balance; Postural responses (APRs); Anticipatory postural adjustments (APAs); Balance during gait; D. What parts of the brain are involved in balance control?
E. What is the role of the basal ganglia in balance control?F. Balance is a complex sensorimotor task that can be improved with practice; Highlights; References; 2 -- Why is balance so important in Parkinson disease?; A. How common are balance disorders in PD?; B. How important are balance and gait to the wellbeing of a person with PD?; C. When do balance problems emerge?; D. Why does Parkinson disease affect balance?; E. How does dopaminergic replacement therapy work?; F. Do dopaminergic mechanisms explain all the balance deficits of parkinsonism?
G. How is balance affected in Parkinson-Plus syndromes?H. Do nonmotor signs affect balance control in PD?; Highlights; References; 3 -- How is balance during quiet stance affected by PD?; Clinical case; A. How does PD affect postural alignment?; B. How are limits of stability impaired in PD?; C. What is the contribution of axial tone to standing balance?; D. Why is postural sway important?; E. Does PD affect sensory integration for balance?; F. Does levodopa improve standing balance?; G. Do other medications influence balance?
H. What are the effects of deep brain stimulation on standing posture?I. Can rehabilitation improve standing posture?; Highlights; References; 4 -- How are postural responses to external perturbations affected by PD?; Clinical case; A. How are retropulsion and propulsion related to impaired postural responses?; B. Why do patients with PD show more abnormalities in their postural responses in the backward direction than other directions ...; C. What are the major postural responses deficits in PD?; D. How does PD affect adaptation of postural responses to changes in environmental context?
E. Does levodopa improve postural responses?F. Does deep brain stimulation improve postural responses?; G. Does rehabilitation improve postural responses?; Highlights; References; 5 -- How are anticipatory postural adjustments in preparation for voluntary movements affected by PD?; Clinical case; A. Are APAs hypometric in PD?; B. Are APAs context-dependent?; C. Does levodopa improve APAs?; D. What are the effects of deep brain stimulation on APAs?; E. Can rehabilitation affect APAs?; Highlights; References; 6 -- How is dynamic balance during walking affected by PD?; Clinical case

This convenient reference provides clinicians with point-of-care guidance on the assessment and treatment of chronic and acute asthma in infants, toddlers, school-aged children, and young adults. This quick reference is perfect to have on hand during evaluation and diagnosis, determination of a treatment course, and communication with patients and parents about asthma triggers, management strategies, a customized treatment plan, and follow-ups. It includes current approaches to asthma diagnosis and management, office pulmonary testing, clinical index tools, stepped approaches to treatment by age, maintenance and control, exacerbations, medication guidance with updated recommendations, and much more. CONTENTS INCLUDE Approach to Evaluation Diagnosis Office Pulmonary Function Testing Exacerbation Assessment Respiratory Scoring Tools Classifying Severity by Age Intervention Overview NIH/NHLBI Stepwise Approaches to Management FeNO: NIH/NHLBI Recommendations GINA Stepped Approaches to Treatment Maintenance and Control SABAs Inhaled Corticosteroids LABAs and LTRAs Inhaled Anticholinergic Agents Systemic Corticosteroids Anti-immunoglobulin E Therapy Other Biologics Trigger Management Exercise-Induced Bronchoconstriction Asthma Control Test Tobacco Use/Vaping and Asthma Get Valid Spirometry Results Every Time

Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient's organism. Investigations into the mechanisms of aspirin-induced asthma.

Bioactive Food as Dietary Interventions for Arthritis and Inflammatory Diseases, Second Edition is a valuable scientific resource that focuses on the latest advances in bioactive food research and the potential benefit of bioactive food choice on arthritis. Written by experts from around the world, the book presents important information that can help improve the health of those at risk for arthritis and related conditions using food selection as its foundation.

Over the past 30 years, there has been increasing recognition of psoriatic arthritis as a distinct clinical entity. Psoriatic arthritis occurs mostly in patients with psoriasis and may affect up to 1% of the general population. It has many similarities to other forms of spondyloarthritis, and must be differentiated from related conditions. Given that most patients with psoriatic arthritis have skin and musculoskeletal diseases that significantly affect their quality of life and function, patients are ideally managed in a multidisciplinary clinic with rheumatologists, dermatologists and a nurse specialist, physical therapist and occupational therapist. Psoriatic Arthritis covers the epidemiology and diagnostic and classification criteria, describing the clinical features of the disease, including skin and nail involvement, articular, and other extra-articular manifestations. Laboratory features and imaging characteristics are covered in detail, along with co-morbidities and their impact. A comprehensive review of skin disease therapy is also provided, along with the various treatment options for joint disease, including traditional disease modifying therapy and newer biologic agents . This comprehensive yet concise and practical volume is the perfect guide to psoriatic arthritis for the busy practitioner, and will be of interest to trainees and specialists in rheumatology and dermatology.

This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

Integrative Rheumatology offers a new and much-needed perspective in disease and symptom management, blending conventional medicine with alternative approaches not typically included in a Western medical practice. While conventional treatments can provide considerable symptomatic relief and can even slow the progression of many rheumatologic conditions, integrative treatment incorporating lifestyle interventions, mind-body approaches, and practices such as acupuncture and meditation into conventional medical therapies can improve quality of life, reduce medication dosages, and are generally better tolerated. In this book, researchers and clinicians highlight specific gaps in conventional rheumatologic care and examine how alternative approaches may be ideally suited to address these missed opportunities. Here, the authors introduce topics not typically addressed in conventional rheumatology texts, including nutritional therapies, exercise, herbal medicine, mind/body approaches, Ayurveda, and energy medicine. The contributors, all of whom have a background in academic medicine, share the approaches that they have found most effective in their own practices, basing their work on the best scientific evidence available. Ultimately, an understanding of complementary and alternative approaches to healing can help clinicians care for their patients using the best proven therapies to modify disease progress and relieve pain and disability. (http://www.amazon.com)

Intro; Title Page; Copyright Page; Contents; Preface; Contributors; List of Abbreviations; Chapter 1 Delivering Musculoskeletal Care Across Boundaries; Introduction; Rheumatology in the community: the impact on primary care; Who should be referred to secondary care?; Musculoskeletal interface services; Further management; Conclusion; References; Chapter 2 Pain in the Wrist and Hand; Functional anatomy; Tendon problems; Flexor tenosynovitis; Finger flexor tendonosis and trigger finger; De Quervainâ#x80;#x99;s tenosynovitis; Extensor tenosynovitis; Mallet finger; Dupuytrenâ#x80;#x99;s contracture
Peripheral nerve entrapment syndromesCarpal tunnel syndrome; Cubital tunnel syndrome; Osteoarthritis; Nodal osteoarthritis; First carpometacarpal osteoarthritis; Systemic disorders causing hand pain; Inflammatory arthritis; Acute pseudogout and chondrocalcinosis of the wrist; Acute gout and chronic tophaceous gout; Diabetic stiff hand (cheiroarthropathy â#x80;#x93; limited joint mobility syndrome); Raynaudâ#x80;#x99;s phenomenon; Other disorders; Ganglion; Chronic (work-related) upper limb pain; Osteonecrosis (rare); Scaphoid bone fracture; Writerâ#x80;#x99;s cramp; Septic arthritis
Complex regional pain syndromeLocal corticosteroid injection technique; References; Further reading; Chapter 3 Pain in the Neck, Shoulder and Arm; Anatomy and function of the neck and shoulder joint; Clinical evaluation; Neck pain; Investigation of neck pain; Treatment of neck pain; Shoulder pain; Rotator cuff disease; Adhesive capsulitis; Other shoulder disorders; Elbow and forearm pain; Lateral and medial epicondylitis; Other elbow disorders; Reference; Further reading; Chapter 4 Low Back Pain; Causes of low back pain; Lumbar spondylosis; Disc herniation; Spondylolisthesis
Spinal stenosisIdiopathic (non-specific) low back pain; Neoplasms; Infection; Assessment; History; Physical examination; Imaging studies; Treatment; Acute low back pain; Chronic low back pain; Nerve root compression syndromes; Further reading; Chapter 5 Pain in the Hip; Hip pain in children; Developmental dysplasia of the hip (DDH); Perthesâ#x80;#x99; disease; Slipped upper femoral epiphysis (SUFE); Septic arthritis; Transient synovitis/â#x80;#x98;irritable hipâ#x80;#x99;; Other arthritides; Hip pain in adults; Osteoarthritis; Other arthritides; Hip fracture; Pagetâ#x80;#x99;s disease; Avascular necrosis; Malignancy
Femoro-acetabular impingement (FAI)Painful soft tissue conditions around the hip; Management of hip pain; Acknowledgement; Further reading; Chapter 6 Pain in the Knee; Traumatic causes of knee pain; Meniscus injury; Articular cartilage injury; Differentiation of cause; Knee pain in younger people and athletes; Patellar tendonopathy; Anterior knee pain syndrome; Pes anserine bursitis; Iliotibial band friction syndrome; Knee pain in older people; Knee pain in systemic disease; Other causes of knee pain; â#x80;#x98;Red flagsâ#x80;#x99;; Further reading; Chapter 7 Pain in the Foot

Overview of the aims and management of rheumatological conditions : the multidisciplinary approach / Krysia Dziedzic ... [et al.] -- The user patient journey / Susan M. Oliver, Ailsa Bosworth -- Initial clinical assessment of patients with possible rheumatic disease / Andrew Hassell, Janet Cushnaghan -- The measurement of patient-reported outcome in the rheumatic diseases / Kirstie L. Haywood -- Applying the biopsychosocial model to the management of rheumatic disease / Sarah Ryan, Alison Carr -- Patient education and self management / Alison Hammond, Karin Niedermann -- The principles of therapeutic exercise and physical activity / Mike V. Hurley, Lindsay M. Bearne -- Physical therapies : treatment options in rheumatology / Lindsay M. Bearne, Mike V. Hurley -- Occupational therapy : treatment options in rheumatology / Lynne Goodacre, Janet E. Harkess -- Joint protection and fatigue management / Alison Hammond -- Applying psychological interventions in rheumatic disease / Elizabeth D. Hale, Gareth J. Treharne.";"Orthotics of the hand / Jo Adams -- Podiatry, biomechanics, and the rheumatology foot / Jim Woodburn, Deborah E. Turner -- Diet and complementary therapies / Dorothy Pattison, Adrian White -- Pharmacological treatments in rheumatic diseases / Benazir Saleem, Philip G. Conaghan -- Inflammatory arthritis / Anne O'Brien, Catherine Backman -- Osteoarthritis / Krysia Dziedzic, Susan L. Murphy, Helen Myers -- Fibromyalgia syndrome and chronic widespread pain / Joseph G. McVeigh, Rachel O'Brien -- Ankylosing spondylitis and the seronegative spondyloarthopathies / Mark L. Clemence -- Osteoporosis / Caitlyn Dowson, Rachel Lewis -- Connective tissue disorders / Janet L. Poole and Jane S. Brandenstein -- Physiotherapy and occupational therapy for children and young people with juvenile idiopathic arthritis / Janine Hackett, Bernadette Johnson -- Miscellaneous conditions / Edward Roddy, David G.I. Scott.

Physical examination of the cervical spine -- Physical examination of the thoracoumbar spine -- General imaging : degenerative conditions of the spine -- General imaging : traumatic conditions of the spine -- Cervical disk herniation -- Cervical spondylosis -- Cervical trauma : upper cervical spine -- Cervical trauma : subaxial cervical spine -- Lumbar disk herniation -- Physical examination for lumbar spinal stenosis -- Lumbar spondylolisthesis -- Lumbar degenerative disk disease -- Thorocalumbar trauma -- Adolescent idiopathic scoliosis -- Scheuermann kyphosis -- Diskitis and vertebral osteomyelitis of the spine -- Primary bone tumors of the spine -- Metastatic disease of the spine

"This is the most comprehensive spine resource available. It is authored by members of the Cervical Spine Research Society, which is the premier society dealing with cervical spine problems. Cervical spine problems are treated by both neurosurgeons and orthopaedic surgeons. We will have a corresponding web site that will contain the book content plus the basic science content and videos of procedures with some updates"--Provided by publisher.

Perfect for hand therapy specialists, hand therapy students, and any other professional who encounters clients with upper extremity issues, Fundamentals of Hand Therapy, 2nd Edition contains everything you need to make sound therapy decisions. Coverage includes hand anatomy, the evaluation process, and diagnosis-specific information. Expert tips, treatment guidelines, and case studies round out this comprehensive text designed to help you think critically about each client's individual needs. Clinical Pearls and Precautions highlight relevant information learned by the experienced author and contributors that you can apply to clinical practice. Case examples included in the diagnoses chapters in Part Three demonstrate the use of clinical reasoning and a humanistic approach in treating the client. Diagnosis-specific information in the final section of the book is well-organized to give you quick access to the information you need. Special features sections such as Questions to Discuss with the Physician, What to Say to Clients, Tips from the Field, and more help readers find their own clinical voices. Online sample exercises give you a pool to pull from during professional practice.

Written for hand therapy specialists and non-specialists, Cooper's Fundamentals of Hand Therapy, 3rd Edition emphasizes treatment fundamentals, and provides tips and guidelines for hand therapy practice. This easy-to-use illustrated text and reference guide helps further develop your clinical reasoning skills by describing what goes into the evaluation process, highlighting the humanistic side of each encounter through case studies, and providing the wisdom the contributing authors have acquired through years of practice. This new edition also features additional chapters on the use of common physical agents and orthoses, plus added content on how to integrate evidence-based findings into daily hand practice. UPDATED! Chapter covering Orthoses Essential Concepts reflects the latest information in the field. Case studies with questions and resolutions help you develop strong clinical reasoning skills while presenting the human side of each client encounter. Special features sections such as Questions to Discuss with the Physician, What to Say to Clients, Tips from the Field, and more help you find your own clinical voice. Anatomy sections throughout text highlight important anatomical bases of dysfunctions, injuries, or disorders. Clinical Pearls highlight relevant information from an experienced author and contributors that you can apply to clinical practice in the future. Evaluation Techniques and Tips help you master appropriate and thorough clinical evaluation of clients. Diagnosis-specific information in the final section of the book is well-organized to give you quick access to the information you need.

"Evaluation and Management of Common Upper Extremity Disorders: A Practical Handbook answers the need for a comprehensive, yet concise reference that addresses practical solutions to everyday conditions that general orthopedic surgeons, and specialists alike, as well those involved with general musculoskeletal surgical and nonsurgical care, may encounter. This book provides information on how to diagnose, treat, and manage the most commonly encountered conditions of the upper extremity. Written in a bullet format, and including photos for quick, easy reference, the book contains valuable information for all levels of training and experience"--Provided by publisher.

Anatomy of upper extremity joints with cadaveric correlation / Aurea V.R. Mohana-Borges and Christine B. Chung -- Technical considerations for MRI of upper extremity joints / Lynne S. Steinbach, Christine B. Chung and Hiroshi Yoshioka -- Clinical evaluation of the painful shoulder / John P. Belzer and Frederic W. Bost -- MRI of the rotator cuff / Lynne S. Steinbach -- MRI of glenohumeral instability / Lynne S. Steinbach -- Long bicipital tendon including superior labral anterior-posterior lesions / Christine B. Chung and Lynne S. Steinbach -- Miscellaneous conditions of the shoulder / Lina Chen and Christine B. Chung -- The postoperative shoulder / Luis S. Beltran, William B. Morrison and Aurea V.R. Mohana-Borges -- Clinical evaluation of the painful elbow / Christina R. Allen and Marc R. Safran -- Elbow ligaments and instability / Christine B. Chung -- Elbow tendons and epicondylitis / Christine B. Chung -- Bone and cartilage injury / Tudor Hughes and Christine B. Chung -- Miscellaneous disorders of the elbow / Christine B. Chung -- Clinical evaluation of the painful wrist and hand / McPherson S. Beall III and Edward Diao -- Wrist ligaments and the triangular fibrocartilage complex / Hiroshi Yoshioka -- The carpal tunnel and Guyon's canal / David Malfair -- Miscellaneous conditions of the wrist / Geoffrey Riley and Lynne S. Steinbach -- MRI of finger ligaments / Christine B. Chung and Rodrigo Aguiar -- MRI of finger tendons / Rodrigo Aguiar and Christine B. Chung -- Miscellaneous disorders of the finger / Christine B. Chung

PE of the shoulder : the basics and specific tests -- General imaging of the shoulder -- Glenohumeral instability -- Labral tears : superior -- Rotator cuff -- Biceps tendon -- Acromioclavicular joint -- Glenohumeral arthritis -- Fractures/trauma

The leading reference on shoulder rehabilitation, Physical Therapy of the Shoulder, 5th Edition provides complete information on the functional anatomy of the shoulder, the mechanics of movement, and the evaluation and treatment of shoulder disorders. It promotes current, evidence-based practice with coverage of the latest rehabilitation and surgical techniques. Case studies show the clinical application of key principles, and follow the practice patterns from the APTA Guide to Physical Therapist Practice, 2nd Edition, relating to shoulder disorders.

Providing a balanced, evidence-based discussion of whiplash and its associated disorders, Whiplash: A Patient Centered Approach to Management compiles information from many sources into a single, definitive reference. It clearly delineates rationales and procedures, covering cervical spine anatomy, neurology, kinesiology, epidemiology, patient history and assessment, imaging, soft tissue injuries, articular lesions, rehabilitation, and prognosis. Using numerous full-color photos and illustrations, an expert author team led by Dr. Meridel Gatterman offers concrete guidelines for a patient-centered approach to care of whiplash and whiplash-related conditions -- one that recommends minimally invasive procedures and therapies whenever possible. A patient-centered approach to care emphasizes working with patients as partners, with both preferring minimally invasive procedures and therapies where appropriate, in a way that promotes self-healing, a holistic approach to the patient, and a humanistic attitude with regard to the patient/practitioner relationship. Coverage of both typical and less common types of whiplash injuries helps you accurately assess varied symptoms and avoid overlooking any related signs and symptoms. Detailed coverage of the relationship between the cervical spine and the cervical distribution of the autonomic nervous system helps you recognize the potential complications of whiplash and how nerve anatomy informs these complications. More than 20 tables and charts provide a quick reference to facilitate review of the material. A glossary provides definitions and pronunciations of terms related to whiplash.